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Article

Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system.

Archives of oral biology - 1 Jun 2008

Ishida Yutaka, Hu Jinping, Sakai Eiko, Kadowaki Tomoko, Yamamoto Kenji, Tsukuba Takayuki, Kato Yuzo, Nakayama Koji, Okamoto Kuniaki

Abstract excerpt

Porphyromonas gingivalis, a major etiological bacterium of periodontal diseases, produces a unique lysine-specific cysteine proteinase (Lys-gingipain, Kgp) implicated in the virulence of this organism. Our observations show the expression of a catalytically active recombinant Kgp in a P. gingivalis Kgp-null mutant and the restoration of its functions by the use of a shuttle plasmid vector stable in P. gingivalis....

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Identifiers

PMID: 18295742
DOI: 10.1016/j.archoralbio.2008.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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