Article
Generation of lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities.
Microbiology (Reading, England) - 1 Aug 2000
Aduse-Opoku Joseph, Davies Nyama N, Gallagher Alex, Hashim Ahmed, Evans Helen E A, Rangarajan Minnie, Slaney Jennifer M, Curtis Michael A
Abstract excerpt
Porphyromonas gingivalis, a black-pigmenting anaerobe implicated in the aetiology of periodontal disease, contains two loci, rgpA and rgpB, encoding the extracellular Arg-X specific proteases (RGPs, Arg-gingipains), and kgp, which encodes a Lys-X specific protease (KGP, Lys-gingipain). The rgpA and kgp genes encode polyproteins comprising pro-peptide and catalytic domain with large N- and C-terminal extensions...
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