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Article

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.

Neurobiology of disease - 1 Jun 2007

Pitsch J, Schoch S, Gueler N, Flor P J, van der Putten H, Becker A J

Abstract excerpt

Altered expression and distribution of neurotransmitter receptors, including metabotropic glutamate receptors (mGluRs), constitute key aspects in epileptogenesis, impaired hippocampal excitability and neuronal degeneration. mGluR1 mediates predominantly excitatory effects, whereas mGluR4 acts as inhibitory presynaptic receptor. Increased hippocampal expression of mGluR1 and mGluR4 has been observed in human...

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Identifiers

PMID: 17446080
DOI: 10.1016/j.nbd.2007.03.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.PMID 17446080Read ↗

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