Article

Glial alterations in the glutamatergic and GABAergic signaling pathways in a mouse model of Lafora disease, a severe form of progressive myoclonus epilepsy

2024-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Lafora disease (LD; OMIM#254780) is a rare form of progressive myoclonus epilepsy characterized by the accumulation of insoluble deposits of aberrant glycogen (polyglucosans), named Lafora bodies (LBs), in the brain but also in peripheral tissues. It is assumed that the accumulation of LBs is related to the appearance of the characteristic pathological features of the disease. In mouse models of...

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Literature Corpus work: f139c860-9eef-593e-9498-39823dcb2bb8
DOI: 10.1101/2024.09.13.612874

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