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Article

No ischemic preconditioning in heterozygous connexin43-deficient mice.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2002

Schwanke Uwe, Konietzka Ina, Duschin Alexej, Li Xiaokui, Schulz Rainer, Heusch Gerd

Abstract excerpt

Protein kinase Cepsilon (PKCepsilon) plays a central role in ischemic preconditioning (IP) in mice and rabbits, and activated PKCepsilon colocalizes with and phosphorylates connexin43 (Cx43) in rats and humans. Whether or not Cx43 contributes to the mechanism(s) of IP in vivo is yet unknown. Therefore, wild-type (n = 8) and heterozygous Cx43-deficient mice (n = 8) were subjected to 30 min occlusion and 120 min...

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Identifiers

PMID: 12234831
DOI: 10.1152/ajpheart.00442.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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