Article
Analysis of B cell selection in the germinal center reaction during a T-dependent antibody response at a single cell level.
Immunology letters - 15 Apr 2008
Okazawa Takahiro, Magari Masaki, Kimoto Takafumi, Kouyama Emi, Ohmori Hitoshi, Kanayama Naoki
Abstract excerpt
The quasimonoclonal mouse is useful to examine B cell selection during T-dependent antibody (Ab) responses because of its limited B cell populations mainly expressing the knockin 17.2.25 V(H)-encoded H chain (V(H)T) paired with the lambda1 or lambda2 L chain. It has been reported that both two V(H)T/lambda1 and V(H)T/lambda2 B cell populations responded to a T-dependent antigen conjugated with a hapten...
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