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Article

Affiliation to mature B cell repertoire and positive selection can be separated in two distinct processes.

International immunology - 1 Mar 2000

Hachemi-Rachedi S, Drapier A M, Cazenave P A, Sanchez P

Abstract excerpt

Using an 'oligoclonal' model, we have previously shown that mice transgenic for a mu chain (H3) and deficient for kappa chain expression display a mature B cell repertoire largely dominated by the H3/lambda1 pair, while the four H3/lambda available combinations can be observed in the immature B cell compartment. This led us to propose the existence of a positive selection process. To test this hypothesis, we have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin kappa-Chains

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Source

Identifiers

PMID: 10700473
DOI: 10.1093/intimm/12.3.385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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