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Article

Imaging of germinal center selection events during affinity maturation.

Science (New York, N.Y.) - 26 Jan 2007

Allen Christopher D C, Okada Takaharu, Tang H Lucy, Cyster Jason G

Abstract excerpt

The germinal center (GC) is an important site for the generation and selection of B cells bearing high-affinity antibodies, yet GC cell migration and interaction dynamics have not been directly observed. Using two-photon microscopy of mouse lymph nodes, we revealed that GC B cells are highly motile and extend long cell processes. They transited between GC dark and light zones and divided in both regions, although...

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Identifiers

PMID: 17185562
DOI: 10.1126/science.1136736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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