Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans.

Molecular biology of the cell - 1 May 2008

Tokuoka Suzumi M, Saiardi Adolfo, Nurrish Stephen J

Abstract excerpt

The antiepileptic valproate (VPA) is widely used in the treatment of bipolar disorder, although the mechanism of its action in the disorder is unclear. We show here that VPA inhibits both inositol phosphate and diacylglycerol (DAG) signaling in Caenorhabditis elegans. VPA disrupts two behaviors regulated by the inositol-1,4,5-trisphosphate (IP(3)): defecation and ovulation. VPA also inhibits two activities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimanic Agents
Share to Diglycerides
Share to Inositol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inositol 1,4,5-Trisphosphate

Share to Inositol 1,4,5-Trisphosphate Receptors

Share to Inositol Phosphates

Share to Ovulation

Share to Phosphatidylinositol 4,5-Diphosphate

Source

Open in PubMed Open full text

Identifiers

PMID: 18287529
DOI: 10.1091/mbc.e07-09-0982
PMCID: PMC2366867

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mood stabilizer valproate inhibits both inositol- and diacylglycerol-signaling pathways in Caenorhabditis elegans.PMID 18287529Read ↗

Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signalingSemantic proximity Read ↗

Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans.Semantic proximity Read ↗

The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans.Semantic proximity Read ↗

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.Semantic proximity Read ↗

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.Semantic proximity Read ↗

A common mechanism of action for three mood-stabilizing drugs.Semantic proximity Read ↗

Gαq Mediates Clozapine Effects in <i>Caenorhabditis</i> elegansSemantic proximity Read ↗

The Role of the UPR Pathway in the Pathophysiology and Treatment of Bipolar DisorderSemantic proximity Read ↗

Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.Semantic proximity Read ↗

Docosahexaenoic Acid Modulates Myo-Inositol and Myo-Inositol Biosynthetic Genes Expression: Implications for Bipolar DisorderSemantic proximity Read ↗

The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.Semantic proximity Read ↗

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.