Article
The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.
Cell - 7 Oct 2005
Norman Kenneth R, Fazzio Robert T, Mellem Jerry E, Espelt Maria V, Strange Kevin, Beckerle Mary C, Maricq Andres V
Abstract excerpt
Rhythmic behaviors are a fundamental feature of all organisms. Pharyngeal pumping, the defecation cycle, and gonadal-sheath-cell contractions are three well-characterized rhythmic behaviors in the nematode C. elegans. The periodicities of the rhythms range from subsecond (pharynx) to seconds (gonadal sheath) to minutes (defecation). However, the molecular mechanisms underlying these rhythmic behaviors are not...
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