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Article

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum.

Disease models & mechanisms - 21 Aug 2018

Kelly Elizabeth, Sharma Devdutt, Wilkinson Christopher J, Williams Robin S B

Abstract excerpt

Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed. Here, we explore the possibility of a diacylglycerol kinase (DGK) playing a role in regulating the effect of VPA relating to the treatment of both disorders, using the biomedical model Dictyostelium discoideum DGK enzymes provide the first...

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Identifiers

PMID: 30135067
DOI: 10.1242/dmm.035600
PMCID: PMC6176992

Genes

DGKA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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