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Article

Activating KIR3DS1: A key driver of KIR3DL1/HLA-Bw4-linked risk in CML.

Human immunology - 1 Jun 2026

Basirat Masoumeh, Mokhtari Maral, Abadi Hassan Ghader, Farjadian Shirin

Abstract excerpt

BACKGROUND: Killer-cell immunoglobulin-like receptors (KIRs) regulate natural killer (NK) cell development and operate by interacting with their cognate ligands, human leukocyte antigen class I (HLA-I) molecules. KIR and HLA-I gene diversity and their independent inheritance can modulate NK cell activity, thereby impacting susceptibility to hematologic malignancies. METHODS: The presence of 11 KIR genes and their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42034883
DOI: 10.1016/j.humimm.2026.111724

Genes

KIR3DS1
KIR3DL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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