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Article

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity.

Cancer cell - 1 May 2005

Zhou Honglin, Du Ming-Qing, Dixit Vishva M

Abstract excerpt

Mucosa-associated lymphoid tissue (MALT) lymphoma is a common type of lymphoma in extranodal sites. The most frequent chromosome translocation associated with MALT lymphoma is t(11;18)(q21;q21), which generates a chimeric protein of c-IAP2 and MALT1/paracaspase. The c-IAP2/MALT1 fusion protein activates the NF-kappaB pathway, which is considered critical to malignant B cell transformation and lymphoma...

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Share to Caspases
Share to I-kappa B Kinase
Share to Lymphoma, B-Cell, Marginal Zone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Translocation, Genetic

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Source

Identifiers

PMID: 15894263
DOI: 10.1016/j.ccr.2005.04.012

Genes

MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity.PMID 15894263Read ↗

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