Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007

Lobry Camille, Lopez Tatiana, Israël Alain, Weil Robert

Abstract excerpt

Activation of the transcription factor NF-kappaB after stimulation through antigen receptors is important for lymphocyte differentiation, activation, proliferation, and protection against apoptosis. Much progress has been made in understanding the molecular events leading to NF-kappaB activation, but how this activation is eventually down-regulated is less well understood. Recent studies have indicated that Bcl10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CARD Signaling Adaptor Proteins
Share to Feedback, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanylate Cyclase

Share to I-kappa B Kinase

Share to Interleukin-2

Share to Proteasome Inhibitors

Share to Threonine

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 17213322
DOI: 10.1073/pnas.0606982104
PMCID: PMC1783413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.PMID 17213322Read ↗

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.Semantic proximity Read ↗

Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.Semantic proximity Read ↗

beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.Semantic proximity Read ↗

Role of NF-kappaB in the control of apoptotic and proliferative responses in IL-2-responsive T cellsSemantic proximity Read ↗

c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.Semantic proximity Read ↗

CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB.Semantic proximity Read ↗

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.Semantic proximity Read ↗

Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.Semantic proximity Read ↗

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100.Semantic proximity Read ↗

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.Semantic proximity Read ↗

Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.Semantic proximity Read ↗

Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.