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Article

Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.

Gynecologic oncology - 1 Oct 2005

Dowdy Sean C, Gostout Bobbie S, Shridhar Viji, Wu Xiaosheng, Smith David I, Podratz Karl C, Jiang Shi-Wen

Abstract excerpt

OBJECTIVE: To measure mRNA expression levels of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines and to determine if DNA methylation is involved in the control of PEG3 expression. METHODS: PEG3 mRNA levels were measured with real-time PCR from 28 gynecologic cancer cell lines and compared to normal tissues. PEG3 mRNA expression was correlated to promoter methylation levels measured by real-time...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16023706
DOI: 10.1016/j.ygyno.2005.05.036

Genes

PEG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.PMID 16023706Read ↗

Imprinted tumor suppressor genes <i>ARHI</i> and <i>PEG3</i> are the most frequently down‐regulated in human ovarian cancers by loss of heterozygosity and promoter methylationSemantic proximity Read ↗

Paternal monoallelic expression of PEG3 in the human placentaSemantic proximity Read ↗

Epigenetic silencing of <i>PEG3</i> gene expression in human glioma cell lines*Semantic proximity Read ↗

An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.Semantic proximity Read ↗

Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification.Semantic proximity Read ↗

The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies.Semantic proximity Read ↗

Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines.Semantic proximity Read ↗

LncRNA-MEG3 inhibits cell proliferation of endometrial carcinoma by repressing Notch signalingSemantic proximity Read ↗

Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinomaSemantic proximity Read ↗

Silencing of Paternally Expressed Gene 10 Inhibits Trophoblast Proliferation and InvasionSemantic proximity Read ↗

Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancerSemantic proximity Read ↗

Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors.Semantic proximity Read ↗

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