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Article

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.

European journal of human genetics : EJHG - 1 Jul 2008

Martínez Alfonso, Santiago José Luis, Cénit M Carmen, de Las Heras Virginia, de la Calle Hermenegildo, Fernández-Arquero Miguel, Arroyo Rafael, de la Concha Emilio G, Urcelay Elena

Abstract excerpt

A recent genome-wide scan of nonsynonymous SNPs and ulterior validation in case-control and family analyses evidenced a susceptibility locus for type 1 diabetes (T1D) on chromosome 2q24.3. We aimed at testing the effect of this locus in other autoimmune diseases with complex genetic background, such as multiple sclerosis (MS). Four SNPs along the locus, rs13422767, rs2111485, rs1990760 and rs2068330, were...

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Topics

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Share to Calcium-Binding Proteins
Share to Chromosomes, Human, Pair 2
Share to DEAD-box RNA Helicases
Share to Ether-A-Go-Go Potassium Channels
Share to Gene Frequency
Share to Interferon-Induced Helicase, IFIH1
Share to Multiple Sclerosis
Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18285833
DOI: 10.1038/ejhg.2008.16

Genes

GCA
IFIH1
KCNH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.PMID 18285833Read ↗

The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Semantic proximity Read ↗

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.Semantic proximity Read ↗

No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.Semantic proximity Read ↗

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.Semantic proximity Read ↗

Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach.Semantic proximity Read ↗

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.Semantic proximity Read ↗

The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.Semantic proximity Read ↗

Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.Semantic proximity Read ↗

The IFIH1-A946T risk variant promotes diabetes in a sex-dependent mannerSemantic proximity Read ↗

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.Semantic proximity Read ↗

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