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Article

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.

European journal of human genetics : EJHG - 1 Jun 2009

Couturier Nicolas, Gourraud Pierre-Antoine, Cournu-Rebeix Isabelle, Gout Claire, Bucciarelli Florence, Edan Gilles, Babron Marie-Claude, Clerget-Darpoux Françoise, Clanet Michel, Fontaine Bertrand, Brassat David

Abstract excerpt

A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19156166
DOI: 10.1038/ejhg.2008.259
PMCID: PMC2947096

Genes

IFIH1
GCA
KCNH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.PMID 19156166Read ↗

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.Semantic proximity Read ↗

No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.Semantic proximity Read ↗

Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Semantic proximity Read ↗

Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the IFIH1 gene with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.Semantic proximity Read ↗

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis.Semantic proximity Read ↗

<i>NR1H3</i> p.Arg415Gln Is Not Associated To Multiple Sclerosis RiskSemantic proximity Read ↗

Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.Semantic proximity Read ↗

The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population.Semantic proximity Read ↗

A novel intergenic variant linked to IFIH1 rs1990760 polymorphism, rs2111485, shows an association with susceptibility to coronavirus disease 2019 and influences IFIH1 protein levels.Semantic proximity Read ↗

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.Semantic proximity Read ↗

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