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Article

No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.

Journal of neuroimmunology - 15 Apr 2010

Bergamaschi Laura, Ban Maria, Leone Maurizio A, Sawcer Stephen J, D'Alfonso Sandra

Abstract excerpt

Studies suggest that different autoimmune diseases share a common genetic background, in particular, an overlap between Multiple Sclerosis (MS) and type 1 diabetes (T1D) susceptibility loci has been established. A recent study found that four rare SNPs in the IFIH1 (interferon induced with helicase C domain 1) were significantly associated with T1D. To establish if these SNPs were also involved in MS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20116863
DOI: 10.1016/j.jneuroim.2010.01.005
PMCID: PMC2854891

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis.PMID 20116863Read ↗

Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach.Semantic proximity Read ↗

The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.Semantic proximity Read ↗

Reduced expression of IFIH1 is protective for type 1 diabetes.Semantic proximity Read ↗

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.Semantic proximity Read ↗

The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Semantic proximity Read ↗

Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1.Semantic proximity Read ↗

IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.Semantic proximity Read ↗

Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.Semantic proximity Read ↗

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.Semantic proximity Read ↗

Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.Semantic proximity Read ↗

Association of the rs1990760, rs3747517, and rs10930046 polymorphisms in the IFIH1 gene with susceptibility to autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

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