Article
Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks.
Infection and immunity - 1 May 2008
García Alexis, Ihrig Melanie M, Fry Rebecca C, Feng Yan, Xu Sandy, Boutin Samuel R, Rogers Arlin B, Muthupalani Suresh, Samson Leona D, Fox James G
Abstract excerpt
Helicobacter hepaticus causes hepatitis in susceptible strains of mice. Previous studies indicated that A/JCr mice are susceptible and C57BL/6NCr mice are resistant to H. hepaticus-induced hepatitis. We used F1 hybrid mice derived from A/J and C57BL/6 matings to investigate their phenotype and determine their hepatic gene expression profile in response to H. hepaticus infection. F1 hybrid mice, as well as...
Topics
- Animals
- Carcinoma, Hepatocellular
- Fatty Acid Synthases
- Fatty Liver
- Female
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Helicobacter Infections
- Helicobacter hepaticus