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Article

Nile Tilapia (Oreochromis niloticus) Patched1 Mutations Disrupt Cardiovascular Development and Vascular Integrity through Smoothened Signaling.

International journal of molecular sciences - 15 Mar 2024

Liu Xiang, Zhao Changle, Liu Lei, Peng Xi, Li Jianeng, Tao Wenjing, Wang Deshou, Wei Jing

Abstract excerpt

Hedgehog (Hh) signaling is crucial in cardiovascular development and maintenance. However, the biological role of Patched1 (Ptch1), an inhibitory receptor of the Hh signaling pathway, remains elusive. In this study, a Ptch1 ortholog was characterized in Nile tilapia (Oreochromis niloticus), and its function was investigated through CRISPR/Cas9 gene knockout. When one-cell embryos were injected with CRISPR/Cas9...

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Identifiers

PMID: 38542295
DOI: 10.3390/ijms25063321
PMCID: PMC10970307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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