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Article

TEX14 is essential for intercellular bridges and fertility in male mice.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006

Greenbaum Michael P, Yan Wei, Wu Meng-Hsieh, Lin Yi-Nan, Agno Julio E, Sharma Manju, Braun Robert E, Rajkovic Aleksandar, Matzuk Martin M

Abstract excerpt

Cytokinesis in somatic cells concludes with the formation of a midbody, which is abscised to form individual daughter cells. In contrast, germ cell cytokinesis results in a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel. During spermatogenesis, proposed roles for the intercellular bridge include germ cell communication, synchronization, and chromosome dosage...

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Source

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Identifiers

PMID: 16549803
DOI: 10.1073/pnas.0505123103
PMCID: PMC1458781

Genes

TEX14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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TEX14 is essential for intercellular bridges and fertility in male mice.PMID 16549803Read ↗

TEX14 Interacts with CEP55 To Block Cell AbscissionSemantic proximity Read ↗

Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.Semantic proximity Read ↗

Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells.Semantic proximity Read ↗

Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermiaSemantic proximity Read ↗

DMRT proteins and coordination of mammalian spermatogenesisSemantic proximity Read ↗

A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.Semantic proximity Read ↗

Mouse germ cell clusters form by aggregation as well as clonal divisions.Semantic proximity Read ↗

Identification of genetic networks that act in the somatic cells of the testis to mediate the developmental program of spermatogenesisSemantic proximity Read ↗

Altered germline cyst formation and oogenesis in Tex14 mutant mice.Semantic proximity Read ↗

The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.Semantic proximity Read ↗

Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertilitySemantic proximity Read ↗

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.Semantic proximity Read ↗

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