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Article

TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.

EMBO molecular medicine - 1 Sept 2015

Yang Fang, Silber Sherman, Leu N Adrian, Oates Robert D, Marszalek Janet D, Skaletsky Helen, Brown Laura G, Rozen Steve, Page David C, Wang P Jeremy

Abstract excerpt

Genome-wide recombination is essential for genome stability, evolution, and speciation. Mouse Tex11, an X-linked meiosis-specific gene, promotes meiotic recombination and chromosomal synapsis. Here, we report that TEX11 is mutated in infertile men with non-obstructive azoospermia and that an analogous mutation in the mouse impairs meiosis. Genetic screening of a large cohort of idiopathic infertile men reveals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26136358
DOI: 10.15252/emmm.201404967
PMCID: PMC4568952

Genes

TEX11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.PMID 26136358Read ↗

<i>Tex11</i> Mutant Mouse Models of Human AzoospermiaSemantic proximity Read ↗

Novel Hemizygous Mutations of TEX11 Cause Meiotic Arrest and Non-obstructive Azoospermia in Chinese Han PopulationSemantic proximity Read ↗

Novel mutations of TEX11 are associated with non-obstructive azoospermia.Semantic proximity Read ↗

X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men.Semantic proximity Read ↗

Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974*Semantic proximity Read ↗

Induced pluripotent stem cell line from a mouse model of human azoospermia with a frameshift mutation Tex11_1260Ins(TT).Semantic proximity Read ↗

Scrutinizing the human TEX genes in the context of human male infertilitySemantic proximity Read ↗

Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.Semantic proximity Read ↗

Regulation of Male Fertility by X‐Linked GenesSemantic proximity Read ↗

Identification of TEX101 functional interactome through proteomic measurement of human spermatozoa homozygous for the missense variant rs35033974Semantic proximity Read ↗

A new TEX11 mutation causes azoospermia and testicular meiotic arrest.Semantic proximity Read ↗

A Novel Compound Heterozygous Mutation in TEX14 Causes Human Non-Obstructive Azoospermia by Disrupting the Assembly of Intercellular Bridges.Semantic proximity Read ↗

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