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Article

Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.

Journal of molecular biology - 23 Jan 2004

Canyuk Bhutorn, Medrano Francisco J, Wenck Mary Anne, Focia Pamela J, Eakin Ann E, Craig Sydney P

Abstract excerpt

Enzymes that salvage 6-oxopurines, including hypoxanthine phosphoribosyltransferases (HPRTs), are potential targets for drugs in the treatment of diseases caused by protozoan parasites. For this reason, a number of high-resolution X-ray crystal structures of the HPRTs from protozoa have been repo...

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Identifiers

PMID: 14698288
DOI: 10.1016/j.jmb.2003.11.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14698288-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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