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Bacterial versus human thymidylate synthase: Kinetics and functionality

1 May 2018

Abstract excerpt

Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of the DNA building block thymidylate. Structurally, functionally and mechanistically, bacterial and mammalian TSases share remarkable similarities. Because of this closeness, bacterial enzymes have long been used as model systems for human TSase. Furthermore, while TSase inhibitors have long served as chemotherapeutic drugs,...

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PMID: 29715278
DOI: 10.1371/journal.pone.0196506

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