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Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis

14 Jan 2021

Abstract excerpt

TROP2 is a type I transmembrane glycoprotein originally identified in human trophoblast cells that is overexpressed in several types of cancer. To better understand the role of TROP2 in cancer, we herein aimed to develop a sensitive and specific anti-TROP2 monoclonal antibody (mAb) for use in flow cytometry, Western blot, and immunohistochemistry using a Cell-Based Immunization and Screening (CBIS) method. Two...

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PMID: 33490649
DOI: 10.1016/j.bbrep.2020.100902

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