Article
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
The Journal of clinical investigation - 1 Oct 2007
Yanagi Shigehisa, Kishimoto Hiroyuki, Kawahara Kohichi, Sasaki Takehiko, Sasaki Masato, Nishio Miki, Yajima Nobuyuki, Hamada Koichi, Horie Yasuo, Kubo Hiroshi, Whitsett Jeffrey A, Mak Tak Wah, Nakano Toru, Nakazato Masamitsu, Suzuki Akira
Abstract excerpt
PTEN is a tumor suppressor gene mutated in many human cancers. We generated a bronchioalveolar epithelium-specific null mutation of Pten in mice [SP-C-rtTA/(tetO)(7)-Cre/Pten(flox/flox) (SOPten(flox/flox)) mice] that was under the control of doxycycline. Ninety percent of SOPten(flox/flox) mice that received doxycycline in utero [SOPten(flox/flox)(E10-16) mice] died of hypoxia soon after birth. Surviving...
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