Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor.

The Journal of biological chemistry - 6 Feb 2004

Guidi Cynthia J, Veal Timothy M, Jones Stephen N, Imbalzano Anthony N

Abstract excerpt

The gene encoding INI1, a component of the mammalian SWI/SNF ATP-dependent chromatin remodeling enzymes, has been classified as a tumor suppressor in humans. Gene-targeting experiments confirmed that Ini1 also functions as a tumor suppressor in mice. Although Ini1-null mice are embryonic lethal, 15-30% of mice heterozygous for Ini1 presented with poorly differentiated tumors with variable rhabdoid features. All...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Heterozygote

Share to Mice, Mutant Strains

Share to Neoplasms, Experimental

Share to SMARCB1 Protein

Share to Transcription, Genetic

Source

Identifiers

PMID: 14630919
DOI: 10.1074/jbc.M312043200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor.PMID 14630919Read ↗

Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.Semantic proximity Read ↗

Genetic ablation of <i>Cyclin D1</i> abrogates genesis of rhabdoid tumors resulting from <i>Ini1</i> lossSemantic proximity Read ↗

Long-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome.Semantic proximity Read ↗

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.Semantic proximity Read ↗

Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors.Semantic proximity Read ↗

INI1-Deficient TumorsSemantic proximity Read ↗

Use of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.Semantic proximity Read ↗

Intact INI1 Gene Region With Paradoxical Loss of Protein Expression in AT/RTSemantic proximity Read ↗

Chromosome mechanisms and INI1 inactivation in human and mouse rhabdoid tumors.Semantic proximity Read ↗

Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.Semantic proximity Read ↗

Germline mutation of INI1/SMARCB1 in familial schwannomatosis.Semantic proximity Read ↗

Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.