Article
Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers.
Cancer research - 15 Feb 2008
Wang Xianshu, Szabo Csilla, Qian Chiping, Amadio Peter G, Thibodeau Stephen N, Cerhan James R, Petersen Gloria M, Liu Wanguo, Couch Fergus J
Abstract excerpt
Inactivating mutations in several genes that encode components of the DNA repair machinery have been associated with an increased risk of breast cancer. To assess whether alterations in other DNA repair genes contribute to breast cancer and to further determine the relevance of these genes to pancreatic cancer, we performed mutational analysis of 32 DNA double-strand break repair genes in genomic DNA from 38...
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