Coding variants in human double-strand break DNA repair genes.

doi:10.1016/s0027-5107(02)00218-x

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Article

Coding variants in human double-strand break DNA repair genes.

Mutation research - 30 Nov 2002

Ruttan Cindy C, Glickman Barry W

Abstract excerpt

DNA repair is essential for the maintenance of genomic integrity. Consequently, altered repair capacity may impact individual health in such areas as aging and susceptibility to certain diseases. Defects in some DNA repair genes, for example, have been shown to increase cancer risk, accelerate aging and impair neurological functions. Now that over 115 genes directly involved in human DNA repair have been...

Topics

Amino Acid Substitution
Chromosome Breakage
Codon
DNA
DNA Repair
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Male
Neoplasms
Polymorphism, Single Nucleotide
Population Surveillance

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Open in PubMed

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PMID: 12427538
DOI: 10.1016/s0027-5107(02)00218-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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