Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic.

Cancer genetics - 1 May 2016

Borecka M, Zemankova P, Vocka M, Soucek P, Soukupova J, Kleiblova P, Sevcik J, Kleibl Z, Janatova M

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among common solid cancer diagnoses. It has been shown that up to 10% of PDAC cases have a familial component. Characterization of PDAC-susceptibility genes could reveal high-risk individuals and patients that may benefit from tailored therapy. Hereditary mutations in PALB2 (Partner and Localizer of BRCA2) gene has been shown to predispose, namely to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Czech Republic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Fanconi Anemia Complementation Group N Protein

Share to Genetic Predisposition to Disease

Share to Nuclear Proteins

Share to Pancreatic Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 27106063
DOI: 10.1016/j.cancergen.2016.03.003

Genes

PALB2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic.PMID 27106063Read ↗

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.Semantic proximity Read ↗

PALB2 mutations in familial breast and pancreatic cancer.Semantic proximity Read ↗

PALB2 mutations in European familial pancreatic cancer familiesSemantic proximity Read ↗

Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated.Semantic proximity Read ↗

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy.Semantic proximity Read ↗

Contribution of germline PALB2 variants to an unselected and prospectively registered pancreatic cancer patient cohort in Pakistan.Semantic proximity Read ↗

PALB2 germline mutations in familial breast cancer cases with personal and family history of pancreatic cancerSemantic proximity Read ↗

Mutations in BRCA1, BRCA2, and PALB2, and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Molecular characteristics of BRCA1/2 and PALB2 mutations in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.