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Article

mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.

The Journal of biological chemistry - 18 Apr 2008

Gusdon Aaron M, Votyakova Tatyana V, Mathews Clayton E

Abstract excerpt

Reactive oxygen species (ROS) play a critical role in the pathogenesis of human diseases. A cytosine to adenine transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt-ND2, human; mt-Nd2, mouse) gene results in resistance against type 1 diabetes and several additional ROS-associated conditions. Our previous studies have demonstrated that the adenine-containing allele (mt-Nd2(a)) is also...

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Source

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Identifiers

PMID: 18281288
DOI: 10.1074/jbc.M708801200
PMCID: PMC2447668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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