Article
Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression.
Oncotarget - 26 Jan 2016
Akiyama Yoshimitsu, Koda Yuki, Byeon Sun-Ju, Shimada Shu, Nishikawaji Taketo, Sakamoto Ayuna, Chen Yingxuan, Kojima Kazuyuki, Kawano Tatsuyuki, Eishi Yoshinobu, Deng Dajun, Kim Woo Ho, Zhu Wei-Guo, Yuasa Yasuhito, Tanaka Shinji
Abstract excerpt
SET7/9, a histone methyltransferase, has two distinct functions for lysine methylation. SET7/9 methylates non-histone proteins, such as p53, and participates in their posttranslational modifications. Although SET7/9 transcriptionally activate the genes via H3K4 mono-methylation, its target genes are poorly understood. To clarify whether or not SET7/9 is related to carcinogenesis, we studied alterations of SET7/9...
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