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Telomere biology in giant cell tumour of bone

7 Feb 2008

Abstract excerpt

Giant cell tumour of bone (GCTB) is a benign bone tumour known for the unpredictable clinical behaviour of recurrences and, in rare instances, distant metastases. It consists of uniformly distributed osteoclastic giant cells in a background of mononuclear rounded and spindle-shaped cells. Cytogenetically, telomeric associations are the most common chromosomal aberrations, which, however, are normally almost...

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PMID: 18278785
DOI: 10.1002/path.2301

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