Article
Analysis of giant cell tumour of bone cells for Noonan syndrome/cherubism-related mutations.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2013
Moskovszky Linda, Idowu Bernadine, Taylor Richard, Mertens Fredrik, Athanasou Nicholas, Flanagan Adrienne
Abstract excerpt
BACKGROUND: Giant cell tumour of bone (GCTB) is an osteolytic tumour which contains numerous osteoclast-like giant cells and a proliferation of mononuclear stromal cells (MSC). Giant cell-rich osteolytic lesions can also develop in the jaw bones in Noonan syndrome, a cherubism-like developmental abnormality that is transmitted in an autosomal dominant fashion, often because of mutation in the PTPN11 or BRAF...
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