Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue.

doi:10.1016/j.humpath.2005.07.005

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Article

Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue.

Human pathology - 1 Sept 2005

Lau Yu Sin, Sabokbar Afsaneh, Gibbons C L M H, Giele Henk, Athanasou Nicholas

Abstract excerpt

Giant-cell tumor of bone (GCTB) and giant-cell tumor of soft tissue (GCTST) are tumors that contain a prominent osteoclastlike giant-cell component. The precise relationship between these morphologically similar tumors is unclear, and the cellular mechanism whereby giant cells accumulate within these and other locally aggressive tumors is uncertain. In this study, we have examined the cytochemical, functional,...

Topics

Apoptosis Regulatory Proteins
Bone Neoplasms
Bone Resorption
Carrier Proteins
Coculture Techniques
Giant Cell Tumor of Bone
Giant Cell Tumors
Glycoproteins
Humans
Immunohistochemistry
Membrane Glycoproteins
Monocytes
Osteoclasts
Osteolysis

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Osteoprotegerin

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RANK Ligand

RNA, Messenger

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Identifiers

PMID: 16153456
DOI: 10.1016/j.humpath.2005.07.005

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