Article
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.
PLoS pathogens - 27 May 2010
Hersperger Adam R, Pereyra Florencia, Nason Martha, Demers Korey, Sheth Prameet, Shin Lucy Y, Kovacs Colin M, Rodriguez Benigno, Sieg Scott F, Teixeira-Johnson Leia, Gudonis Debbie, Goepfert Paul A, Lederman Michael M, Frank Ian, Makedonas George, Kaul Rupert, Walker Bruce D, Betts Michael R
Abstract excerpt
Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates using ex vivo cells have been identified with the known ability to cause the direct elimination of HIV-infected cells. We have recently discovered the ability of human CD8(+) T-cells to rapidly...
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