Article

Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

2021-02-24

Abstract excerpt

HIV-1 leads to progression to immunodeficiency and death of individuals who do not receive successful antiretroviral therapy. Initially, the host’s immune response controls the infection, but cannot eliminate the HIV-1 from the host. Cytotoxic lymphocytes are the key effector cells in this response and can mediate crucial antiviral responses through the release of a set of proteases called granzymes towards HIV-1-...

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Literature Corpus work: 3f862ada-7f32-55aa-877e-45548326d6a1
DOI: 10.1101/2021.02.24.432686

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