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Cross‐Reactive Memory CD8+T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice in a Sequence‐Specific Manner

14 Feb 2008

Abstract excerpt

Dengue virus is the causative agent of dengue fever and the more-severe dengue hemorrhagic fever (DHF). Human studies suggest that the increased risk of DHF during secondary infection is due to immunopathology partially mediated by cross-reactive memory T cells from the primary infection. To model T cell responses to sequential infections, we immunized mice with different sequences of dengue virus serotypes and...

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PMID: 18275279
DOI: 10.1086/526790

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