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Conserved MHC Class I–Presented Dengue Virus Epitopes Identified by Immunoproteomics Analysis Are Targets for Cross-Serotype Reactive T-Cell Response

13 Jan 2012

Abstract excerpt

Dengue fever and dengue hemorrhagic fever are significant global public health problems, and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive T-cell...

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PMID: 22246683
DOI: 10.1093/infdis/jir814

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