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Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells

4 Jul 2018

Abstract excerpt

How previous immunity influences immune memory recall and protection against related flaviviruses is largely unknown, yet encounter with multiple flaviviruses in a lifetime is increasingly likely. Using sequential challenges with dengue virus (DENV), yellow fever virus (YFV), and Japanese encephalitis virus (JEV), we induced cross-reactive cellular and humoral immunity among flaviviruses from differing...

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PMID: 29978039
DOI: 10.1126/sciadv.aar4297

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