Article

Decreased K <sub>ATP</sub> channel activity contributes to the low glucose threshold for insulin secretion of rat neonatal islets

2021-03-05

Abstract excerpt

Transitional hypoglycemia in normal newborns occurs in the first 3 days of life and has clinical features consistent with hyperinsulinism. We found a lower threshold for glucose-stimulated insulin secretion from freshly isolated embryonic day (E)22 rat islets, which persisted into the first postnatal days. The threshold reached the adult level by postnatal day (P)14. Culturing P14 islets also decreased the glucose...

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Literature Corpus work: 604e5a69-b49c-566e-8674-cc87934795fb
DOI: 10.1101/2021.03.04.433947

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