A rapid, microplate SNP genotype assay for the leptinob allele.

doi:10.1194/jlr.D800002-JLR200

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Article

A rapid, microplate SNP genotype assay for the leptinob allele.

Journal of lipid research - 1 May 2008

Oler Angie T, Attie Alan D

Abstract excerpt

A nonsense mutation in the mouse leptin gene causes genetic obesity. As a result of extensive research in the field of obesity, the use of leptinob mice is widespread. This mutation renders mice sterile, creating the need to breed heterozygous mice. For this reason, leptinob genotyping is necessary. To date, gel-based assays have been used for genotyping. Using the Invader Plus assay for single nucleotide...

Topics

Animals
DNA
Genetic Variation
Genotype
Humans
Leptin
Mice
Mice, Obese
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 18272929
DOI: 10.1194/jlr.D800002-JLR200

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