Article
Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy.
Cancer science - 1 Feb 2008
Saito Kana, Sakurai Shinji, Sano Takaaki, Sakamoto Kazuha, Asao Takayuki, Hosoya Yoshinori, Nakajima Takashi, Kuwano Hiroyuki
Abstract excerpt
To identify additional alterations to c-kit or platelet-derived growth factor receptor alpha (PDGFRA) genes in gastrointestinal stromal tumors (GIST), we investigated the methylation status of nine known methylation-sensitive CpG islands (p15, p16, p73, 0-6-methylguanine-DNA methyltransferase, E-cadherin, mutL homolog 1, colon cancer nonpolyposis type 2 (escherichia), methylated in tumors [MINT]1, MINT2, and...
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