Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor.

doi:10.1002/ijc.29088

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor.

International journal of cancer - 1 Mar 2015

Haller Florian, Zhang Jitao David, Moskalev Evgeny A, Braun Alexander, Otto Claudia, Geddert Helene, Riazalhosseini Yasser, Ward Aoife, Balwierz Aleksandra, Schaefer Inga-Marie, Cameron Silke, Ghadimi B Michael, Agaimy Abbas, Fletcher Jonathan A, Hoheisel Jörg, Hartmann Arndt, Werner Martin, Wiemann Stefan, Sahin Ozgür

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) have distinct gene expression patterns according to localization, genotype and aggressiveness. DNA methylation at CpG dinucleotides is an important mechanism for regulation of gene expression. We performed targeted DNA methylation analysis of 1.505 CpG loci in 807 cancer-related genes in a cohort of 76 GISTs, combined with genome-wide mRNA expression analysis in 22 GISTs,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gastrointestinal Stromal Tumors

Share to Genome, Human

Share to Oligonucleotide Array Sequence Analysis

Share to Osteopontin

Share to Survival Rate

Source

Open in PubMed

Identifiers

PMID: 25046773
DOI: 10.1002/ijc.29088

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined DNA methylation and gene expression profiling in gastrointestinal stromal tumors reveals hypomethylation of SPP1 as an independent prognostic factor.PMID 25046773Read ↗

A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancersSemantic proximity Read ↗

Identification of DNA methylation‑driven genes by integrative analysis of DNA methylation and transcriptome data in pancreatic adenocarcinomaSemantic proximity Read ↗

SPP1 is a Prognostic Related Biomarker and Correlated with Tumor-Infiltrating Immune Cells in Hepatocellular CarcinomaSemantic proximity Read ↗

SPP1 Might Be A Novel Prognostic Biomarker For Patients With Malignancy: A Meta-Analysis And Sequential Verification Based on Bioinformatic AnalysisSemantic proximity Read ↗

SPP1 Might Be a Novel Prognostic Biomarker for Patients With Malignancy: a Meta-analysis and Sequential Verification Based on Bioinformatic AnalysisSemantic proximity Read ↗

Multi-Transcriptomic Analysis Reveals the Heterogeneity and Tumor-Promoting Role of SPP1/CD44-Mediated Intratumoral Crosstalk in Gastric CancerSemantic proximity Read ↗

SPARC and DNA methylation: Possible diagnostic and therapeutic implications in gastrointestinal cancersSemantic proximity Read ↗

Genomic and transcriptomic landscape of human gastrointestinal stromal tumors.Semantic proximity Read ↗

Higher Expression of SPP1 Predicts Poorer Survival Outcomes in Head and Neck CancerSemantic proximity Read ↗

The Significance of Secreted Phosphoprotein 1 in Multiple Human CancersSemantic proximity Read ↗

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinomaSemantic proximity Read ↗

Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumourSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.