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Article

SDHC methylation in gastrointestinal stromal tumors (GIST): a case report.

BMC medical genetics - 28 Sept 2015

Urbini Milena, Astolfi Annalisa, Indio Valentina, Heinrich Michael C, Corless Christopher L, Nannini Margherita, Ravegnini Gloria, Biasco Guido, Pantaleo Maria A

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GIST) recently have been recognized as a genetically and biologically heterogeneous disease. In addition to KIT or PDGFRA mutated GIST, mutational inactivation of succinate dehydrogenase (SDH) subunits has been detected in the KIT/PDGFRA wild-type subgroup, referred to as SDH deficient (dSDH). Even though most dSDH GIST harbor mutations in SDHx subunit genes, some are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gastrointestinal Stromal Tumors

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Membrane Proteins

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 26415883
DOI: 10.1186/s12881-015-0233-7
PMCID: PMC4587653

Genes

SDHC
KIT
PDGFRA
SDHA

Provenance

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