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Article

Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells.

Developmental cell - 1 Feb 2008

Smith Kelly A, Chocron Sonja, von der Hardt Sophia, de Pater Emma, Soufan Alexander, Bussmann Jeroen, Schulte-Merker Stefan, Hammerschmidt Matthias, Bakkers Jeroen

Abstract excerpt

We have used high-resolution 4D imaging of cardiac progenitor cells (CPCs) in zebrafish to investigate the earliest left-right asymmetric movements during cardiac morphogenesis. Differential migratory behavior within the heart field was observed, resulting in a rotation of the heart tube. The leftward displacement and rotation of the tube requires hyaluronan synthase 2 expression within the CPCs. Furthermore, by...

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Identifiers

PMID: 18267096
DOI: 10.1016/j.devcel.2007.11.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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