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Article

Chemokine Signaling Controls Endodermal Migration During Zebrafish Gastrulation

21 Aug 2008

Abstract excerpt

Directed cell movements during gastrulation establish the germ layers of the vertebrate embryo and coordinate their contributions to different tissues and organs. Anterior migration of the mesoderm and endoderm has largely been interpreted to result from epiboly and convergent-extension movements that drive body elongation. We show that the chemokine Cxcl12b and its receptor Cxcr4a restrict anterior migration of...

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PMID: 18719251
DOI: 10.1126/science.1160038

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