Article
Allelic variation of the porcine alpha-1,3-galactosyltransferase 1 (GGTA1) gene.
Journal of applied genetics - 1 Jan 2008
Day Andy, Rocha Dominique
Abstract excerpt
The alpha-1,3-galactosyltransferase 1 enzyme (GGTA1) produces the alpha-Gal epitopes, responsible for pig-to-human hyperacute xenograft rejection. Recently, efforts have been directed at inactivating the porcine GGTA1 gene in order to reduce hyperacute rejection. As very little is known about the genetic variability of this key gene among pig breeds, we investigated the variation in its nucleotide sequence, by...
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