Article
Molecular characterization, chromosomal location, alternative splicing and polymorphism of porcine GFAT1 gene.
Molecular biology reports - 1 Jul 2010
Liu K, Wang G, Zhao S H, Liu B, Huang J N, Bai X, Yu M
Abstract excerpt
Glutamine: fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme of the hexosamine synthesis pathway, which plays important roles in insulin resistance and glucose toxicity. GFAT1 is one of the two isoenzymes of GFAT. In the present study, we cloned cDNA sequence of the porcine GFAT1 gene and identified a GFAT1 splice variant (designed GFAT1-L) that contains a 54 bp insertion within the coding...
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