Article
Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland.
Breast cancer research and treatment - 1 Jun 2010
Czarnecka Anna M, Krawczyk Tomasz, Zdrozny Marek, Lubiński Jan, Arnold Rebecca S, Kukwa Wojciech, Scińska Anna, Golik Paweł, Bartnik Ewa, Petros John A
Abstract excerpt
Mitochondria are subcellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells, but...
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